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THE

(PSILOCYBIN)

MAGIC

(PSILOCYBIN)

 MUSHROOM INTERACTION CHECKER

Receive an instant, evidence-informed report on psilocybin mushroom interactions with your medications and health conditions.

Psychotropic Interactions are Just the Beginning.

Providers, state regulators, and facilitator training programs often have partial information about drug interactions with psilocybin, usually limited to psychotropic categories like antidepressants, antipsychotics, and lithium. In reality there are many--some potentially more serious or relevant than psychotropics. The good news is drug interactions don't have to end the possibility of a safe and supportive journey. Building broader awareness helps reduce risks and support better outcomes. Learn more.

  • HIPAA Compliant Confidential and built with HIPAA-level security
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  • Licensed Professionals Developed by licensed professionals for harm reduction purposes
Before psilocybin journeys, every single person should download Fireside's app and,
if they take prescription medications, consult this tool.
- Josh White, Founder of Fireside Project
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Dr. Kristin Speer (she/her), PharmD, developed this tool. She is a mother, a psychedelic pharmacist and board-certified pharmacotherapy specialist in Colorado. See her full bio and why she created the tool.


Dr. Speer leads the tool’s content development which is maintained by a team of psychedelic pharmacists with PharmD degrees and expertise in psilocybin pharmacology and drug interactions.

ENTER MEDICATIONS:

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FEATURE BASIC REPORT

see an example

 		DETAILED REPORT

see an example
Assigns an estimated risk level to the interaction
Reports interactions with MICRO-dosing, if applicable
Checks interactions with MACRO-dosing (i.e. journey), if applicable
Evidence-based
Includes references ---
Indicates if tapering or holding (skipping) a medication is necessary, if applicable ---
Interactions with context of MACRO-dosing, if/as applicable
(e.g., lying down, environmental temperature, fasting, etc.)
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Interactions with Health Conditions (FDA-labelled indications) for the medication selected, if/as evidence is available ---
Risk factors that increase likelihood or risk of interaction
(e.g., frequency of use, dosage, organ function, age, etc.)
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Strategies to avoid or reduce risks
(e.g., monitoring considerations, who should not take, etc.)
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Supporting context and rationale
(e.g., involved receptor, enzyme/metabolic interactions, etc.)
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CHOOSE REPORT TYPE
(Price automatically adjusts at checkout depending on number of medications entered)

Up to 5 meds: $5

6-10 meds: $10

Up to 5 meds: $25

6-10 meds: $35
Voucher/Coupon Number (Optional):

“INTERACTION REPORT” will appear on the credit card statement.
By purchasing, you affirm that you have read the below DISCLAIMER and COPYRIGHT NOTICE.

5% minimum of profits will be gifted to Indigenous communities

Total Amount

$0
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COPYRIGHT NOTICE: Copyrights have been registered with the US Copyrights Office. All rights reserved. No part nor the whole of any report may be used, reproduced, copied (including photocopied), recorded, distributed, posted, published or processed by any means--including through AI systems, machine learning models, large language models, or other automated tools or electronic methods, without prior written permission of the copyright holder. Sharing a report is permitted only to coordinate or inform harm reduction or healthcare activities related to the use of psilocybin or psilocybin mushrooms by the individual for which this report was intended.



DISCLAIMER: The information in the report is for educational purposes only and is intended to reduce the risk of harm due to potential interactions between psychedelic substances and medications used in the outpatient or community setting (i.e. outside of a hospital or urgent/acute environments). Neither this site/tool nor the report are condoning or encouraging the use of illicit substances; it is recommended you follow all laws applicable to your jurisdiction. The information in the report is based on medical and scientific evidence, which is limited but rapidly growing. The information may change as research evolves. It should not be construed as medical advice or medical clearance. Always follow the advice and direction of your healthcare provider(s). Do not attempt to stop or make changes to your medications or care plans on your own, as this can be dangerous. Be advised there can be many other factors that contribute to your overall risks of using psilocybin mushrooms or other psychedelic substances that should be considered in addition to interactions with your medications or health conditions. By submitting, you agree that you are responsible for the accuracy of the medications and email submitted, and that your use of this site and the interaction report is at your sole risk. You shall be solely responsible and liable for any damages resulting from the information you provide. You agree that you do not and will not hold the creators of this site/tool or report responsible or liable for any damage you may suffer resulting from any errors or omissions on the form or report; nor for any outcomes related to their use.

It is important to keep in mind that magic mushrooms are made of thousands of compounds, not just psilocybin. Yet there is extremely little evidence to guide or predict how those compounds might interact with your medications or health conditions. Thus, much of the information provided via this tool is based on studies and known mechanisms of the psilocybin compound. However, the reported interactions consider and include any evidence based on natural psilocybin mushrooms wherever possible.

FAQ

Yes, there are real and credible drug interactions with psilocybin. While some believe psilocybin has very few or no interactions, that’s not supported by current evidence. Most of the interaction information we have comes from psychiatry, since people often use psilocybin alongside antidepressants or other psychotropic medications. But psilocybin is now being explored across broader populations with more chronic diseases, which means we need to think beyond just psychiatric meds.

 

Take GLP-1 receptor agonists as an example. These are medications like semaglutide or liraglutide, commonly used for diabetes or weight management. There are potentially serious safety concerns when combined with psilocybin, and there are ways to reduce and manage the risks.

 

It’s important to remember that not every interaction means “avoid psilocybin”. Many can be navigated safely with the right knowledge and planning.

 

For those who are hesitant to try psilocybin because they’re on medications, this tool can help validate low-risk combinations, build confidence and help ensure a more predictable, supportive experience. The goal isn’t to block use, but to guide safe, thoughtful application.

No. This tool reports on interactions between psilocybin and each of your medications, individually. This tool does not check for interactions between all your medications. If you take several medications, it is important to consult a pharmacist or your provider on the current interaction risks between all your medications before taking psilocybin. Also keep in mind that it’s possible for psilocybin to carry a low or moderate risk with each individual medication you take, but the combination of all your medications with psilocybin can increase overall risks.

The report comes attached as a PDF to the email address you enter above. The email is discreet and does not mention anything about the nature of the interaction report. The sender of the email will appear as “Interaction Checker”.

Reports should arrive within a minute or so. Be sure to check your spam folder. However, some firewalls will even block spam from being received. If you do not see a report within a few minutes that comes from “Interaction Checker”, please let us know via the feedback button at the bottom of our site. In most cases we respond within 24h, but often sooner, and we’ll send the report directly to you while we look into any technology issues.

Yes. We want you to be satisfied! But if you’re not, we’d like to make things right. Please inform us of your issue via the Feedback button at the bottom of the site and include your name and email. If we can’t fix the issue or meet your needs, we’re happy to issue a refund.

 

You might be thinking this information should be free, or on the other hand, scratching your head about why we don’t charge more. Either way, we believe the information we provide is valuable. Personal resources and thousands of expert hours went into this tool. There were no private equity or venture capital dollars attached to the creation of this tool. While we recoup our own costs and hopefully make a little extra, we consider it just as important to make the information affordable, unbiased and high quality for our users. If we get enough business, we aim to make the basic report available for free.

 

Check that you’ve correctly spelled the medication, as misspellings are the most common issue. Try searching by the generic name rather than brand. If still no luck, it is possible your medication is not yet listed–sometimes due to very limited or no evidence, but also due to the fact that there are over 20,000 FDA approved medications, and probably more over-the-counter supplements and herbals! You may request a medication be added. Submit it via the Feedback button at the bottom of the page, and we’ll review for potential addition. If so, we’ll let you know if you include an email.

 

Alternatively, consider a consultation to check all medications and over-the-counter products together with psilocybin, including any products that are not currently listed in the database. A consultation has the additional benefit of assessing the whole mix, and within the context of your specific case, whereas the interaction reports address each interaction individually with psilocybin. 

 

While the evidence supporting many interactions with psilocybin is limited, it is growing rapidly. Some interactions have stronger and better-quality evidence than others. When the risk of a medication’s use with psilocybin appears more likely and/or serious, we estimate the overall interaction risk to be “moderate”, “moderate to high” or “high”. Any “low” or “low to moderate” risk estimate indicates no interactions are identified or expected; or interactions are not considered serious; or they are potentially serious but uncommon/rare.

Please note reported interactions, like all drug interactions, are not guaranteed to happen, nor do they never happen. They are predicted possibilities which can be impacted by additional risk factors and context of use, and they can change based on available clinical evidence and pharmacology data.

Yes, the report distinguishes whether the interaction applies to MACRO-doses and/or MICRO-doses. If the report does not specify what type of dose (i.e. it just says “psilocybin”), then the information applies regardless of psilocybin dose.

Our interaction database currently includes 300 of the most commonly prescribed generic medications, along with their brand-name equivalents, totaling approximately 700 searchable options. We also include some non-prescription substances, supplements, and herbal products. Our primary focus is on medications used in outpatient or community settings (i.e. formulations and uses outside of an inpatient hospital or urgent/acute environments).

Our focus is on medications approved for use in the United States. However, many international generics have similar pharmacology and interaction risks as their US counterparts. We recommend searching by the generic name rather than brand name, since the same brand name used in the US and another country can represent different generics or active ingredients.

It’s possible the information might apply to these populations, but often they will not. This is because these populations have different care goals and life expectancies which may shift the overall context and risk level of an interaction. This tool can be used to inform decision making, but it is best to discuss overall risks vs benefits with a hospice or palliative provider who understands the patient’s unique case.

We include references when they relate to a potential interaction with psilocybin or classic psychedelics. We use mainly primary and secondary sources of literature, but include some tertiary sources when applicable and appropriate. Due to lack of evidence assessing real outcomes when psilocybin and specific medications are taken together, some interactions are estimated based on pharmacology or adverse effects that are shared by both the medication and psilocybin. Medication pharmacology and adverse effects are published in many sources (FDA labeling is one example), but we did not include these references since they are widely and publicly available and because they don’t include psilocybin interaction data. If you’d like the source we used that lists a medication’s pharmacology or adverse effect, please reach out via the Feedback button on our site and we’ll send it to you!

We are a small team of licensed pharmacists who hold PharmD (doctorate of pharmacy) degrees and expertise in psychedelic pharmacology, drug interactions, and evidence searching & evaluation. Some are residency-trained and board-certified. This is a woman-owned business established by one of the founders of the Psychedelic Pharmacists Association. However, the tool is unaffiliated with the Psychedelic Pharmacists Association.

Not yet. Due to psilocybin’s popularity, accessibility and inclusion in many state drug reform initiatives, we decided to start with it first. Depending on demand, feedback and other factors, we may add reports for DMT/ayahuasca, 5-MeO-DMT, LSD, MDMA, ibogaine, mescaline/peyote, etc.

As licensed healthcare professionals, we deeply respect your need and concerns for confidentiality and wish to uphold your trust. This is why we use military-grade (AES 256-bit) encryption, a server built for HIPAA-level security (HIPAA Vault), secure email, and ask for the minimum amount of information: just medication names and an email address to send the report. (We wouldn’t know if the meds and email you enter are yours or someone else’s anyway!)

We want to know! Please notify us via the Feedback button at the bottom of our site. Please include relevant details about the issue. For report issues, it will help to include the email address where the report was sent so we can research the related issue or the content that was requested.

Yes. When the tool is profitable, a minimum of 5% profits will go to Indigenous Communities in Colorado and potentially other states. If the tool becomes more successful, we plan to increase that amount.

Please submit your question via the Feedback button below. We will do our best to get back to you in a timely manner. Please note we cannot provide interaction details via the Feedback feature or direct email. If needed, consultation services are available.

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