THE

(PSILOCYBIN)

MAGIC

(PSILOCYBIN)

MUSHROOM INTERACTION CHECKER

The report comes attached as a PDF to the email address you enter above. The email is discreet and does not mention anything about the nature of the interaction report. The sender of the email will appear as “Interaction Checker”.

Very soon! And we’ll have package options, too. Estimated availability is Q2 2025. Go here if you’d like to be notified as soon as they’re live.

Reports should arrive within a minute or so. Be sure to check your spam folder. However, some firewalls even block spam from being received. If you do not see a report within a few minutes that comes from “Interaction Checker”, please let us know via the feedback button at the bottom of our site. In most cases we respond within 24h, but often sooner, and we’ll send the report directly to you while we look into any technology issues.

Yes. We want you to be satisfied! But if you’re not, we’d like to make things right. Please inform us of your issue via the Feedback button at the bottom of the site and include your name and email. If we can’t fix the issue or meet your needs, we’re happy to issue a refund.

You might be thinking this information should be free, or on the other hand, scratching your head about why we don’t charge more. Either way, we believe the information we provide is valuable. Personal resources and thousands of expert hours went into this tool. There were no private equity or venture capital dollars attached to the creation of this tool. While we recoup our own costs and hopefully make a little extra, we consider it just as important to make the information affordable, unbiased and high quality for our users. If we get enough business, we aim to make the basic report available for free.

Check that you’ve correctly spelled the medication and have searched by the generic name. If still no luck, it is possible your medication is not yet listed. There are over 20,000 FDA approved medications, and probably more over-the-counter supplements and herbals! We would love to know what you need so we can research and add it. Please provide the medication name via the Feedback button at the bottom of our site and we will work as quickly as possible to research interaction information and add it to the site. If you include your email, we’ll let you know when it’s ready.

While the evidence supporting many interactions with psilocybin is limited, it is growing rapidly. Some interactions have stronger and better-quality evidence than others. When the risk of a medication’s use with psilocybin appears more likely and/or serious, we estimate the overall interaction risk to be “moderate”, “moderate to high” or “high”. Any “low” or “low to moderate” risk estimates indicate no interactions are identified or expected; or interactions are not considered serious; or they are potentially serious but uncommon/rare. Please note reported interactions, like all drug interactions, are not guaranteed to happen, nor do they never happen. They are predicted possibilities which can be impacted by additional risk factors, and they can change based on available clinical evidence and pharmacology data.

Yes, the report distinguishes whether the interaction applies to MACRO-doses and/or MICRO-doses. If the report does not specify what type of dose (i.e. it just says “psilocybin”), then the information applies regardless of psilocybin dose.

No. This tool reports on interactions between psilocybin and each of your medications, individually. This tool does not check for interactions between all your medications. If you take several medications, it is important to consult a pharmacist or your provider on the current interaction risks between all your medications before taking psilocybin. Also keep in mind that it’s possible for psilocybin to carry a low or moderate risk with each individual medication you take, but adding psilocybin to the whole mix can increase overall risk.

Our interaction database includes over 250 of the most commonly prescribed generic medications, along with their brand-name equivalents, totaling around 650 searchable options. We also include some non-prescription substances, supplements, and herbal products. Our primary focus is on medications used in outpatient or community settings (i.e. formulations and uses outside of an inpatient hospital or urgent/acute environments), and on those approved for use in the United States. However, many international generics have similar pharmacology and interaction risks as their US counterparts.

It’s possible the information might apply to these populations, but often they will not. This is because these populations have different care goals and life expectancies which may shift the overall context and risk level of an interaction. This tool can be used to inform decision making, but it is best to discuss overall risks vs benefits with a hospice or palliative provider who understands the patient’s unique case.

We include references when they relate to a potential interaction with psilocybin or classic psychedelics. We use mainly primary and secondary sources of literature, but include some tertiary sources when applicable and appropriate. Due to lack of evidence assessing real outcomes when psilocybin and specific medications are taken together, some interactions are estimated based on pharmacology or adverse effects that are shared by both the medication and psilocybin. Medication pharmacology and adverse effects are published in many sources (FDA labeling is one example), but we did not include these references since they are widely and publicly available and because they don’t include psilocybin interaction data. If you’d like the source we used that lists a medication’s pharmacology or adverse effect, please reach out via the Feedback button on our site and we’ll send it to you!.

We are a small team of licensed pharmacists who hold PharmD (doctorate of pharmacy) degrees and expertise in psychedelic pharmacology, drug interactions, and evidence searching & evaluation. Some are residency-trained and board-certified. This is a woman-owned business established by one of the founders of the Psychedelic Pharmacists Association.

Not yet. Due to psilocybin’s popularity, accessibility and inclusion in many state drug reform initiatives, we decided to start with it first. Depending on demand, feedback and other factors, we may add reports for DMT/ayahuasca, 5-MeO-DMT, LSD, MDMA, ibogaine, mescaline/peyote, etc.

As licensed healthcare professionals we understand and strictly observe HIPAA and other healthcare regulations. More importantly, we deeply respect your need and concerns for confidentiality and wish to uphold your trust. This is why we use military-grade (AES 256-bit) encryption and ask for the minimum amount of information: just medication names and an email address to send the report. (We wouldn’t know if the meds and email you enter are yours or someone else’s anyway.)

Yes. We are providing education for harm reduction purposes. Providing education to reduce potential risks and improve safety (just like with opioids, marijuana and other substances) are legitimate and professional activities. This resource is not to condone or encourage the use of illicit substances where they are illegal. We do not sell substances

We want to know! Please notify us via the Feedback button at the bottom of our site. Please include relevant details about the issue. For report issues, it will help to include the email address where the report was sent so we can research the content that was requested

Yes. A minimum of 5% profits will go to Indigenous Communities in Colorado and potentially other states. If the tool becomes more successful, we plan to increase that amount.

Please submit your question via the Feedback button below. We will do our best to get back to you in a timely manner. Please note we cannot provide interaction details via the Feedback feature or direct email. We do not provide consultation services at this time.